Synthesis and Antimycobacterial, Antifungal, and Photosynthesis-Inhibiting Evaluation of Some Anilides of Substituted Pyrazine-2-carboxylic Acids

Condensat ion of chlorides of subs t i tu ted pyrazine-2-carboxylic acids with r ing-subst i tu ted anilines yielded a series of anilides of 6-chloropyrazine-2-carboxylic, 5-( l , l -d imethyle thyl)pyrazine-2carboxylic or 6-chloro-5-(l , l-dimethylethyl)pyrazine-2-carboxylic acids. P r o d u c t s were tes ted for their ant imycobacterial , antifungal, and photosynthesis-inhibit ing activity. Some of t h e m exhibited significative activity against Mycobacterium tuberculosis (inhibition > 50 % a t MIC =,.12.5 fig c m 3 ) . T h e most active compound (88 %) was 6-chloro-5-(l , l -dimethylethyl)pyrazine-2-carboxylic acid 3-fluoroanilide.